Samizdat announces the release of Malcharist by Paul John Scott. This is a grippingly realistic page-turner about the corruption of clinical trials told through the crisis of conscience of a medical ghostwriter.
Set in Manhattan in 2010 and laced with dark humor throughout its fast 352 pages, it finds Shivani Patel in its opening chapters in a Town Car with a private driver, “off to recharge the fading hopes of the neurotransmitter era”.
The reader has already met a clinical trial participant experiencing a terrible side effect, a magazine journalist desperate for paying work of any kind, and now the highest-paid ghost writer for Krøhn-McGill Pharmaceuticals is suiting up to assist the world’s largest drug-maker with marketing a spin-off drug to a room full of Key Opinion Leaders in training.
Patel writes medical journal articles for authors TBD, doing so with data summaries generated by Contract Research Organizations. Hers is work destined to become the evidence base as we know it, including clinical study reports, letters to the editor, review articles, commentaries, published clinical trials and CME.
She is also, unfortunately, “a relic from the weak, pre-industrialized evidence base,” according to her marketing director, “a scientist first, with all the risk that entailed.”
The plot never slows, switching chapter between the viewpoints of an interconnected cast of characters who bring this panoramic tale about the industrialization of medicine in our time to life, including:
- a down on-his-luck magazine writer who is cajoled into promoting a new pill by a slick PR pitch
- a telegenic KOL who has parlayed medical ghostwriting to fame, overstaying his welcome with his well-financed masters
- a trial participant who has developed a terrifying preoccupation with death
- a pharmaceutical marketing director who needs to make another 7 figures so that he can cash out and move to Florida
- a widow who is seduced by a strangely well-endowed patient advocacy group
- a regulatory boss who pals around with drug industry goblins on his weekend cycling trips.
Their paths intersect around a new drug that is the subject of a vigorous indication creep. A drug that has been rebuilt from an old drug, one itself having been rebuilt from an even older drug, a real-life medication that may just have helped take the life of Ernest Hemingway.
We would tell you more but would rather you take the journey yourself.
We can tell you this: it is a work of fiction about subjects that never appear in fiction, including akathisia, miscoding, protocol-switching, data-dredging, me-too drugs, CRO’s, KOLs, monoamines, astroturf groups, the illusion of data transparency, all wrapped up in a thriller that will have you turning to the last page – and open doors to discussing the shortcomings of SSRIs and other drugs in polite company..
Paul has the writing skills to fold this all too real world into dialogue that will leave you in stitches in places and terrified in others. You can buy it on Samizdat and through Amazon and soon on Lulu and Indiebooks.
If you like it, please Tweet, write a review on Amazon, a riff for Samizdat, all the above or any other way you can think of that will get it into the hands of those who need to know that this is what lies behind that nice doctor who says he has just the pill for you – the latest wonder of medical science.