Crusoe was called to see Lisbeth. The girl - young woman was mute and catatonic by day but after she fell asleep she had nightmares when she wailed piteously, rent her nightdress, walked in her sleep muttering ‘the children, the children’ or other such phrases. It was a similar pattern each night, the parents said. The dreams seemed to repeat. Crusoe came in the evening when … [Read more...] about The Girl Who Was Not Heard When She Cried Wolf
101 Uses for a Dead Journal
There used to be a wonderful cartoon series called 101 Uses for a Dead Cat, which led me 25 years ago to give a talk at a British Association for Psychopharmacology meeting entitled 101 Uses for a Dead Psychiatrist. That was back in the days when Psychopharmacology meetings were places of debate and the British Journal of Psychiatry was guaranteed to have something of real … [Read more...] about 101 Uses for a Dead Journal
The Shipwreck of the Singular
Crusoe’s first appearance was in The Creation of Psychopharmacology, where in recognition of the tensions inherent in medicine between the numerous who enter clinical trials and the single person being treated by a doctor, the book opened with a quote from George Oppen’s Of Being Numerous, in which he notes that: “Crusoe we say was rescued”. Since Oppen wrote these lines, … [Read more...] about The Shipwreck of the Singular
The Data Access Wars
This is the first of three Crusoe posts. For background on Crusoe, see Watch where you wave that wand, The Oedipus Effect, The Tree must go. Beta Centauri was unquestionably a long way from Massachusetts. Somewhat to her surprise Crusoe found breathing no problem, and the temperature seemed just about right. The scenery as they’d come in was not unlike that of a … [Read more...] about The Data Access Wars
Access To Clinical Trial Data: Privacy rights, property rights and phoney rights
At the European Medicines’ Agency meeting held on November 22nd convened to look at the issue of Access to Clinical Trial Data, the pharmaceutical companies came armed with an approach signaled a few weeks earlier by GSK’s Andrew Witty (see Won't get Fooled Again). The industry panelists came from Lilly and UCB along with a representative from EurorDis Francois … [Read more...] about Access To Clinical Trial Data: Privacy rights, property rights and phoney rights
Access to RxISK Data: Conflicts of Interest
Won’t get fooled again outlined a stunning propaganda coup by GSK. On the back of a campaign for open access to clinical trial data that has drawn its inspiration from efforts by the Cochrane Tamiflu reviewers to get access to Roche’s clinical trial data, Andrew Witty came out and proclaimed that GSK were all in favor of access to clinical trial data. The BMJ threw its hat in … [Read more...] about Access to RxISK Data: Conflicts of Interest
Won’t Get Fooled Again? GlaxoSmithKline and Access to Data
On November 22nd the European Medicines’ Agency (EMA) is holding a workshop on access to the data from clinical trials. While there have been many efforts by many people over the years to make the clinical trial process more transparent, the EMA workshop has come about primarily following the efforts of Peter Gøtzsche of the Danish Cochrane Group and Peter Doshi and Tom … [Read more...] about Won’t Get Fooled Again? GlaxoSmithKline and Access to Data
The St Bartholomew’s Day Massacre: Protestant Patients, Catholic Drugs
Margot's lover in La Reine Margot was one of the Huguenots who survived the massacre set in train by her brother Charles IX on St Bartholomew's Day in Paris in 1572. There are many politicians, bureaucrats, doctors and others, the Royalists, in a position to make a difference who know that psychotropic drugs can cause suicide or other serious problems but who instead attempt … [Read more...] about The St Bartholomew’s Day Massacre: Protestant Patients, Catholic Drugs
La Reine Margot: Data access, ghostwriting, suicide and mad reviewers
Another study giving a first hint of the findings in our 2012 Mortality in Schizophrenia paper (See The Madness of Psychiatry) was published in the British Journal of Psychiatry in 2006 - Lifetime Rates of Suicide in Schizophrenia. It took several years and some smuggling to get it into print. In the course of exploring the issues, it seemed useful to touch base with Herb … [Read more...] about La Reine Margot: Data access, ghostwriting, suicide and mad reviewers
Benefit Risk Madness: Antipsychotics and Suicide
Following the posting of The Madness of Psychiatry, there has been a flurry of activity in the twittersphere with Louis Appleby, the UK's suicide czar posting: What makes adolescents act on suicidal thoughts? New paper shows psychotic symptoms increase risk 20-fold. archpsyc.jamanetwork.com/article.aspx?a… You might get the impression from this that all patients have to do … [Read more...] about Benefit Risk Madness: Antipsychotics and Suicide