Dr Munchausen: Pharmacophile

Editorial Note:  This piece was first submitted to the J of Mental Health in 1997 and two other journals later that year – with Marie Savage and Phil Thomas as co-authors.  The reviewers were affronted – one figured mental health was likely no worse than the rest of medicine. Unable to find a home, it migrated to become a chapter in the third edition of Psychiatric Drugs Explained.   

Those not part of the biological mainstream of psychiatry say they are committed to being biopsychosocial, rather than bio-bio-bio.  But in fact part of what drove this piece was seeing psychotherapeutically oriented psychiatrists prescribe far more medication and do so abusively in a way that was shocking to someone like me who was dyed in the wool biological.  Its not about bio or psycho or social, its about Power.  The key question to a doctor is not are you biological or social but are you comfortable handing over power.

When antidepressants and antipsychotics were first introduced, doctors prescribed and patients took what they were given. The prescription of a medicine now assumes that a patient should understand the condition for which the prescription is given, the nature of any treatment, its duration, its chances of success and the risks of side effects. Patients should be free to ask for any information they want from the prescriber, who will respond genuinely.

Clearly, respect for the autonomy of the patient has to be balanced against a respect for the autonomy of others. Uniquely in psychiatry it is necessary on occasion to give treatment without consent, but society has put mechanisms in place to compensate for a patient’s loss of autonomy, although it is rarely noticed that despite these arrangements patients detained within mental health settings often have fewer rights than prisoners. The argument outlined below does not apply to these emergency situations or situations where clinicians may be operating with partial or grudging consent from patients. The argument is aimed at situations, where a paternalistic approach to patients may involve an insidious loss of autonomy that may be counter-therapeutic and ethically dubious.

The Problem

Many patients, when first admitted to hospital, will be started on medication regimens that they will not know exceed local or national formulary limits and greatly exceed the regimens that have been shown by research to be optimally effective. They are unlikely to know that there is rarely a pharmacological justification for the co-prescription of two different oral antipsychotics or for a combination of both an oral and depot antipsychotic, or for cocktails of anticonvulsants and antipsychotics.

If given an anticholinergic agent they may not know that this has been given as an antidote to the side effects of the primary medication. If they do know this, they are unlikely to know that, quite commonly, it would be possible to avoid the need for an anticholinergic agent by lowering the antipsychotic dose.

If they are on a combination of antidepressants and antipsychotics, they almost certainly will not know that their ‘depression’ may be a consequence of treatment with antipsychotics and, if so, will not be responsive to antidepressant medication.

Or patients admitted to hospital may have their treatment discontinued abruptly with a new treatment started immediately with little or no consideration given to the possibility of withdrawal from the earlier treatment. In practice antidepressants and antipsychotics are treated as though switching from one to another involved no more than switching between vitamins. This is not the case. Putting someone on a psychotropic drug is more like giving them a pharmacological life event.

Against this background, it seems certain that in clinical practice betrayals of trust occur, and that situations may arise that are ‘abusive’. To what extent do the dynamics that are familiar from the sexual abuse or paedophile arenas apply in this domain.

The Dynamics of Abuse

As in other forms of abuse, a ‘victim’ of ‘abusive prescribing’ may be dependent on the ‘abuser’. This dependence may stem from an unavailability of psychiatric services in the victim’s area other than through the prescriber, and by virtue of the unavailability of psychotropic compounds other than by prescription. The victim, therefore, may have to maintain an interaction with the perpetrator and may in the process have to cope with the fact that the perpetrator at some level may be regarded as showing concern for them.

A common response to this point is that there is a difference between the intent to take advantage of children found in child abuse and the worst that clinicians can be accused of.  Doctors do not casually or deliberately ‘violate’ their patients. This probably overestimates the degree of conscious intent to harm in many cases of child abuse and sexual harassment and underestimates the harm that can be done by clinicians ‘who know best’.

As with other forms of abuse, there will necessarily be a low incidence of disclosure to others, for a number of reasons.

  • First, it is necessary to disclose the illness in order to disclose the abuse, and victims may understandably be reluctant to do this.
  • Second, there may be a legitimate fear of reprisals should complaints be made, which many suspect might take the form of an increase in the dose of the treatment being complained about.
  • Third, in addition to being seen as ill, just as any other victim of abuse, a victim of abusive prescribing risks further stigmatization as victim and as ‘loser’.
  • Fourth, there are difficulties in ventilating concerns as complaining about nervousness and other problems as a consequence of treatment leaves the person open to the perception that all that has been demonstrated is the problem that led to the initial prescription. Indeed, many may not make the connection between their treatment and the way they are feeling. It may only be when they are evaluated by someone else that they become aware of a connection between their treatment and symptoms such as anxiety, depression, demotivation, fatigue, psychosomatic symptoms, nervousness, impulsiveness, irritability, weight gain, sexual disturbances, suicidality, and emotional blunting.
  • Finally, if a patient complains, there will often be a lack of support from significant others. Indeed, there may be considerable external pressure on the individual – from relatives and friends as well as from mental-health professionals – to internalize blame. This will lead to a sense of defectiveness on the patient’s part. This is compounded by blanket company denials that treatment could cause problems and indeed company suppression of the data indicating that there can be problems.
  • As with other forms of abuse, unpredictability may make things worse, as may the duration of the abuse, the extent to which the abuse pervades all aspects of the subject’s life, and the extent to which prescribing is seen as reactive to conflicts rather than aimed at rational and agreed therapeutic ends. Particular difficulties are raised in the case of violent incidents in clinical settings. In such circumstances mental-health staff risk assuming the role of both judge and jury.
  • Ongoing abuse has also traditionally found justification from evidence that the discontinuation of treatment leads to serious problems. This is interpreted as a re-emergence of the illness, a situation that, ethically, all but demands the resumption of treatment. However, what is typically taken as a new illness episode following a reduction or discontinuation of medication may often be evidence of a dependence syndrome.

Droit de Seigneur

Some of this potential for abuse may arise from the prescription-only status of medicines. A significant reason for the extension of prescription-only arrangements to all medicines in the 1950s lay in an assessment that the amount of information regarding the proper use of the new medications was too extensive to fit on the label and that making the drugs available only on prescription-only would ensure that any information a patient needed would be given to them by their prescriber.

One consequence of prescription-only status is that it is not only when a patient has been formally detained that a prescriber is given more than the usual amount of power in determining the outcome of a clinical condition. Every writing of a prescription involves a potential deferral to a medical opinion in a manner that does not happen when people manage their own conditions by non-pharmacotherapeutic means or by means of over-the- counter medications or health food supplements.

The problem looks like it applies in the case of all medications, given recent indicators that drug-induced conditions are now the fourth leading cause of death and may lead to up to one-third of admissions to hospital but it may apply with extra force in the case of the psychotropic agents, in that the problematic effects of medication are most pernicious in this domain.

Grappling with Abuse

Where womens’ movements have been able to lobby effectively for a consideration of sexual abuse and harassment both on a legal level and in terms of raising consciousness in society, patients have fewer levers available to them and are more vulnerable.

The situation in fact is likely to get worse rather than better.  Pharmaceutical companies have been gearing up in recent years to increase sales by increasing compliance.  All the tricks used to sell us things we do not need in other areas of life are set to be deployed into health and mental health – from loyalty cards, to mobile phones with text messaging to remind us to have our meds.  Nurses are being donated to mental health teams to ensure the patient stays on the company’s medication.  Company input to the formation of guidelines makes it increasingly difficult not to prescribe the latest drug.  And increasingly doctors are only paid if they reach targets which specify having a certain percentage of patients with particular conditions on treatment.

Politicians and service managers are being sold the message that 85% of readmissions are linked to non-compliance, at a huge annual cost that could be saved if compliance were ensured.  More ominously perhaps companies talk the language of relationships, education and joint expertise in a way that mental health professionals have not.   It is becoming and will become even more difficult to step back from this – how Dr Healy do you justify denying a patient a treatment that works or colluding with them to avoid treatment?

Awareness of the Problem

As with sexual harassment and other forms of abuse, there has been a tendency to put up with the situation as an inevitable fact of life. Many will think that the extent of and consequences of abusive prescribing hinted at here are overstated.  Many will feel that, if things were this bad, more would have been made of the problem before this.

The failure to recognize the problem may stem from the extent to which we ourselves have been abused. Most medical and nursing staff, while training, will have been instructed by their superiors at various times to administer doses of medication that they considered were unwarranted. Most colleagues I trained with will have seen haloperidol narcosis being administered to young female patients who were not unduly disruptive. This involved giving haloperidol 10 mg intravenously every hour for several days at a stretch. In the hospital where I worked until the mid-1990s, the standard regimen on which all admitted psychotic patients were commenced – even frail women in their sixties – was haloperidol 10 mg four times daily. Regimens of up to 1000 mg per day of flupentixol (equivalent to 20 000 mg chlorpromazine) were not uncommon in the management of young women until recently

Indeed, it is a moot point as to whether the benefits of monotherapy with clozapine stem from the fact that owing to a fear of triggering fits patients are less at risk of prescription abuse from this.

The experiences of researchers working with healthy volunteers here are of relevance. Some researchers have, for example, made videos of the effects of small doses of antipsychotics on these subjects, who are transformed so much that they appear to be indistinguishable from patients who are thought to have schizophrenia with predominantly negative features. Similar outcomes have been recorded using rating scales such as the Positive and Negative Symptoms Scales: volunteers develop ‘negative’ symptoms. In the main, these findings have not reached the public domain owing to concerns among researchers that their impact would damage healthy volunteer research.

A single 5 mg dose of droperidol given blind to healthy volunteers will invariably produce agitation and dysphoria, even suicidality in some. These effects can last up to a week. Alcohol and taking to bed, in an effort to minimize external stimulation, may be one of the best ways to handle the problem. But these behaviors when undertaken by patients, of course, are taken as indicators of illness. The views of patients that a considerable part of the problem may be drug induced are typically discounted.


A vignette may bring some of the issues home. MC is a 65-year-old well- educated articulate woman who became depressed for the first time in her life. She had concomitant osteoporosis that restricted the choice of antidepressant medication that might have suited her. She was accordingly put on sertraline. After several weeks on this she developed chest pain, probably anginal, and breathlessness. After attendance at a clinic, I wrote to her general practitioner recommending a change from this antidepressant. He did nothing. A follow-up letter copied to the patient, suggesting that this was selective serotonin reuptake inhibitor (SSRI)-induced angina and an SSRI-induced respiratory dyskinesia, again advising a change of medication from SSRIs, also had no effect.

The doctor’s interpretation was that the angina was unrelated to her treatment. He interpreted her breathlessness as panic attacks, and therefore as evidence that she should continue with treatment and preferably with an SSRI. The woman herself continued with treatment, afraid that if she stopped, given her evident problems, and had to call her general practitioner out in an emergency and he were to find that she had gone against his instructions he would refuse to treat her when she really needed it. The general practitioner was finally persuaded to change to a non-SSRI, and after several weeks MC’s chest pains and breathlessness cleared up.

This vignette illustrates how dependent people can become in therapeutic situations. Children are almost certainly even less capable of maintaining their perceptions of drug-induced abnormality in the face of contradictory interpretations from both clinicians, and their parents.

This is not just a theoretical issue.  In recent years, there has been a huge increase in antidepressant and antipsychotic prescribing to children, with estimates that there are several million prescriptions per year in the USA alone. This increase has taken place even though the randomized trials of these drugs undertaken in pediatric populations have shown no benefit of the drugs over placebo. There is an ethical issue as to whether this kind of treatment should take place at all in the face of so much negative evidence but, more to the point, the potential for abuse would seem to be huge in such situations.

The Management of Abuse

As with other situations of abuse, the adverse effects of abusive prescribing will remain invisible as long as the existence of abusive prescribing remains unacknowledged. If recognized, it may be possible to put a cost on the consequences of such prescribing. This cost may be substantial if the increased hospitalization, compromised compliance and decreased employment resulting from abusive prescribing are taken into account.

The doctrine that medical practices are all but immune to prosecution if a significant minority of the profession can be shown to practice similarly means that, in the case of abusive prescribing, a legal recourse is unlikely to be helpful in all but the most extraordinary cases. This will be the case even though the documentary proof of abuse in the form of a prescription record is likely to be available in a way that evidence in the case of child abuse or sexual harassment rarely is. Few people will want to take legal action, anyway, partly because they may fear it will affect their relations with all prescribers and not just with one.

The potential for abuse is inherent in all therapies and, in practice, may occur just as much in psychotherapy as in routine pharmacotherapy. The question of abuse in therapy formed the heart of the key legal case in this area, the Osheroff case, in which an individual who was depressed was treated for 9 months with psychotherapeutic approaches that had not been shown to work. Subsequent treatment with antidepressants brought about a prompt improvement in his condition, but this was too late to save his marriage or his job.

The issues were debated at length in the pages of the American Journal of Psychiatry Osheroff 1, Osheroff 2, Osheroff 3, Osheroff 4. In brief, there was no agreement that therapy should necessarily follow evidence of efficacy, but there was agreement that persistence with one therapeutic line, in the face of a lack of progress without a genuine review of other options, was indefensible.

The Osheroff case makes it clear that it would be good practice for all therapists, including pharmacotherapists, to specify what outcomes they are aiming at, the period of time for which they are likely to persist in a particular course of action in the face of non-response or partial response, and what other treatment options they would consider should the current course of treatment fail to deliver the expected benefits.

However, it is possible to go further. Just as the Mental Health Act is supposed to sanction the treatment that would be given to the detained patient as if their relatives were present to witness what was being done, so also, if the prescription-only status of psychotropic agents is not to be revoked, therapists ideally should do pharmacotherapy with the genuineness they would bring to bear if a medical relative or advocate were present with the patient to monitor what was happening – and this should involve some recognition that if a relative or friend of mine had a serious psychosis we really know very little about what to do and anything other than genuine teamwork in such situations cannot be defended.


Medicine has become the Religion of our day – the Opium of the Masses.  It took a very long time to discover abuse and pedophilia in institutions like the Catholic Church.  It may be particularly difficult to do so when it comes to an institution that people feel they have little option but to believe in.

RxISK: Research and report prescription drug side effects on RxISK.org.

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Pharmaceutical companies have hijacked healthcare in America, and the results are life-threatening.


Dr. David Healy documents a riveting and terrifying story that affects us all.


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  1. Thanks again dr. Healy, excellent post.

    So perhaps the only way of reducing the ‘abuse’ in mental Healthcare is to spread the Word among people that doctors, though highly intelligent and well educated, are nowhere near to fully understand psychotropic drugs?

    That your doctor can easily mistake a side-effect as an ‘evidence’ for his initial assumption?

    That your doctor may have Heard alot of strange side-effects contributed by the drug your taking, but even if you exhibit one of them, is more likely to Think you are to blame, that you really are mentally ill? (Even though you have absolutely no history of that particular behaviour)

    That your doctor, in all well meaning, will increase your dose or add Another medication to prevent the new behaviour? (The behaviour that could be a side-effect….)

    The downward spiral is a fact by now, the patient will not be the one to recognise it. Perhaps the patients relatives will, posthumously.

  2. I think the other parallel with sexual abuse is that when questioned, challenged and brought to account, psychiatrists who over prescribe engage in minimising, defending, justifying and victim blaming. This even when a child dies from the adverse effects of prescribed psychotropic drugs as my child did. Classic abusers behaviour.

  3. Doctors often claim that the term “abuse” is unfair because they are well-intentioned. I would argue that being “well-intentioned” is defined by a person’s actions, not simply by quoting the phrase.

    Surely a well-intentioned rapist is still a rapist.

    Patients who report side-effects are told that they are wrong, laughed at, lied to, criticised for not trusting the doctor, described as mentally ill in the notes, and are coerced into continuing with harmful medications. Doctors seem to get some kind of perverse enjoyment from exerting power over patients.

    And finally, when the doctor is proved wrong, they don’t care. They tell the patient that if they aren’t happy with the treatment they have received, they should go somewhere else.

    Well-intentioned? Bullshit.

    Is it abuse? Damn right it is.

    • Doctors seem to get some kind of perverse enjoyment from exerting power over patients ”

      Yes like some social workers. Its termed sadistic schadenfreude disease.

      Yes and pedophiles love children – but child rape is child rape.

      The word pedophilia gives the energy signature that the child rapist cares about his/her victim. They do not.

      Baltimore- the child rapists tried to get it legalised.

      All the insane pseudo research from Kinsey, based on words of convicted pedophiles is being taught to judges etc in 2014 and so few service users and parents know.

      The Kinsey Coverup refers to the paid efforts of the mass media and the Kinsey Institute scientific establishment lobby to hide the facts of child sex abuse and fraud as the basis of Kinsey’s alleged “scientific data” on human sexuality. Spiking legislative investigations into these barbaric “scientific” crimes and Liam Neeson’s glossy portrayal of Kinsey in the 2004 Kinsey feature film, qualify as part of this 60 year plus cover-up.”

  4. Craig newnes says:

    Sorry David, you’re wrong about the church. Families and the church knew about sexual assault by priests from day one. It is solely the availability of mass communication that makes it clear to non-catholics.

    • David_Healy says:


      Was about to say clearly if someone is abused that person knows – but this isn’t true either. Many children will have been very uncertain about what is going on. Something however changed and people are much more likely to tackle the issues now – I suspect its got little to do with non-Catholics finding out – because they all seem to be in comparable boats.

      But the real question is what has to change in order to give patients a voice when drug treatment goes wrong?

  5. Victims began to speak of their abuse. Others then realized that they too had been victims. In the past families had been misled by their faith in the god like clergy and disbelieved the victim. But people were forced to listen. The abusers and the cover ups were outed. The sheer scale of the abuse has shocked the world and rocked the church.
    Within medicine a different shocking abuse is costing lives and impoverishing people.
    We all need to change our beliefs. We need to become informed and question our doctors more.
    The family doctor must stop being a patsy for the Pharma industry.
    He /She must put their patient’s welfare first.

  6. Thank you Dr Healy for your ongoing good work on trying to raise “the patient’s” voice…Is it a case of Pharmacovigilance – v – Pharmacoeconomics – where clinical trials are done on unsuspecting patients – without informed consent – thereby “allowing” good doctor to supply and prescribe pharma drugs of body destruction…”the human guinea pig” is then passed on for pharma clinical trials of further abuse to “the patient”…clinical trials are being done on patients under “minor operations” and good doctor is protected by psychiatry at every turn….Just as in the cases of The Magdalene women…sure who would believe “the patient” against the good reputations of doctors…one good doctor and he had been a very good doctor until “the patient” suffered adverse side effects of a Pharma drug…This good doctor stated “you will get no where with this and the Medical Council will do nothing on this…how right he was…Three years on the hounds of Pharma continue their torture…as for “the drug”, I believe it has made millions for Pharma…

  7. In Drogheda we all knew what was going on and dare anyone speak out against the hospital doctors like Eerie Neary and others. The symphysiotomy business was well known too and spoken of as ” well women are supposed to suffer, married or not. Gosh I can hear it in my head still.

    Some of carried cards asking never to be brought to that hospital even in an emergency.
    Most of us teachers went North to have babies, some to protestant hospitals in Dublin.
    Even my Dad knew in 1954 when I was born in a Protestant hospital as he did not want his wife, our mother to be forced to suffer for the big Sinnnnn of motherhood and they were married.

    When the nurse revealed re Neary, what happened to her? as a reminder to all the others to keep their mouths shut.

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