Sexual Dysfunction Enduring After Treatment Halts: s-DEATH

February, 11, 2014 | 21 Comments


  1. There has been one SSRI-type drug marketed for premature ejaculation: dapoxetine, brand-name Priligy. It’s never quite got FDA approval in the US, but it looks like they are still trying … it may have been licensed in some other places. It’s claimed to be “rapidly absorbed and eliminated”, providing all the benefits of an SSRI and none of the drawbacks.

    The authors also claim that “Pharmacotherapy of PE with off-label antidepressant selective serotonin reuptake inhibitors (SSRIs) is common, effective and safe.” I wouldn’t bet the farm on it …

  2. When it comes to this area all I can say is i’ve been left ‘Helen Keller-ed’, sadly doctors are just as incompetent perhaps even more so today than they were decades or even centuries ago!

  3. “Once established, it appears for at least some people to last forever”

    There is not one single story of a cure. PSSD seems to last forever, for ALL people.

  4. Thank you, thank you, thank you… for helping us get the word out. I am one of the sufferers of Post SSRI Sexual Dysfunction. We need to be heard loud and clear. Thank you for listening and shouting along with us!

  5. The Medicines and Healthcare Products Regulatory Agency Are Ignoring Their Data On PSSD.

    I have had PSSD in the form of Impotence for the last 18 years following a brief period of Prozac just after my 18th birthday, becoming impotent after beginning Prozac and having since never had a proper erection to this day. Following numerous medical tests Doctors have attributed my impotence to the Prozac I took in 1996. I reported the persistence of my Prozac induced impotence to the MHRA using the Yellow Card Scheme but my report was not acknowledged.

    Years later, in 2008 when PSSD had become more widely known about and studies into the persistence of PSSD had begun to be published I began writing to the MHRA. Initially they informed me of a mere 83 Adverse Drug Reaction reports of SSRI-induced sexual dysfunction with 8 of the reports being of sexual dysfunction persistent after discontinuation. After I pressed them further, and they changed their database search criteria they came back with a figure of over 1000 reports of anti depressant induced sexual dysfunction with over 200 being persistent, and over 100 persisting at the time that they were reported to the MHRA.

    Through persistent Freedom Of Information Act requests I`ve got Sarah Cumber, Pharmacovigilance Information Co-ordinator to make the very damning admission that the MHRA have no record of following up the 940 reports of Adverse Drug Reactions of SSRI-related sexual dysfunction they received prior to June 2006 when they claim a change to their database resulted in this information being lost.

    Leaving aside how pathetic and unbelievable an excuse this was, surely it should be expected that the MHRA would have done whatever it could to retrieve the follow up information on these reports of adverse drug reactions? Once the change to the database had occurred shouldn’t they have been doing all possible to contact the patients who made their reports to record the outcome of their adverse drug reactions?

    Well the MHRA didn`t. It took them over 4 years following the alleged loss of follow up information, to by August 2010, follow up any of the reports and it was only in response to my ongoing Freedom Of Information Act Requests probing into their follow up on reports of PSSD that the MHRA made any attempt to retrieve this information.

    The MHRA stated that in August 2010 they chased up only 32 of the 940 Adverse Drug Reactions received prior to their database change of whom none responded. I do not find it plausible that 32 patients who went to the effort to report their sexual dysfunction via the Yellow Card Scheme would ignore correspondence from the MHRA enquiring into the outcome of the adverse effects that they reported.

    Despite that the MHRA had to admit that they retain contact information for 892 of the 940 patients who made their reports prior to the alleged loss of follow up information, the MHRA has refused to contact any more of them.

    In summary the MHRA`s performance in relation to PSSD is as follows, and I will be happy to send the documented evidence of this to anyone who requests the information;

    The MHRA have no record of following up any of the 940 reports relating to SSRI induced adverse sexual effects received prior to June 2006

    In August 2008 they initially informed me that they had received only 83 reports of Adverse Drug Reactions relating to SSRI induced adverse sexual effects and assured me that the matter was under “close review”.

    Only by August 2010 did they follow up any of the adverse drug reaction reports which they now admit were 940 in number, and they followed up only 32 of them claiming none responded.

    In their most recent response to my Freedom Of Information Act request dated 8th November 2013 the MHRA admitted that out of 1220 reports of SSRI Induced sexual dysfunction received, 266 of the reports were of adverse sexual effects that persisted after the patient stopped taking the drug.

    Despite that 1087 reports contained the Patient`s contact information, to date only 117 have been followed up and this number of follow ups has been achieved only through persistent information requests and efforts to keep account of their responses to adverse drug reaction reports.

    The MHRA remain unprepared to provide even a precautionary warning regarding the persistence of SSRI-induced sexual dysfunction and in spite of all the overwhelming evidence, have never been prepared to refer to the persistence of SSRI induced sexual dysfunction as anything more than a “potential signal” as to a symptom of the medication.

  6. I have to wade in here because I think it is relevant to this discussion.
    It is so morally wrong.

    Do we really expect anything else from our MHRA?
    You have to wonder what they actually do, under the direction, of Ian Hudson, ex Glaxo Safety Officer…just file away all complaints, with not a lick of a promise?
    A Filing Officer is not what we want from Our MHRA

    Back to Statins, for one moment.
    Professor Colin Baigent, Co-author of a pro-statins study wrote today in the National Press where two opposing arguments were put forward.
    The more credible was by Dr. Aseem Malhotra who ended his lengthy opposition to saturating us with statins by saying – whatever, NICE says, you won’t need those statins at all.

    Prof Baigent said:

    “taking a statin leads to just one in 10,000 people experiencing *such problems* and surely it’s better to take this very small risk in return for the much bigger chance of avoiding a potentially fatal heart attack or stroke?

    Do, the math, 65 million of us live in the UK, divided by 10,000?

    So, poor Joe Soap, who is the 1 in 10,000 has to live with his life jeopardised because Prof Baigent has given the most contemptible disregard for human life.

    “As for the suggestion that the only people who will benefit from the wider prescription of statins are the share-holders of the pharmaceutical companies, this is looking at things the wrong way round”.

    “NICE is simply recommending that a wider range of people should be offered the opportunity to take them if they wish.”

    We have all been victim to doctors pushing on us drugs that we would rather not have. We don’t sit in the exulted position of a doctor having *the knowledge*.
    We sort of trusted them and so I would say that when a doctor gives a patient an opportunity, he is not, in, fact, doing that at all.
    We do not take them, if we wish.
    The patient is in a position where it is almost impossible to say no.

    Compare this to anti-depressants:

    If this same argument applies, as to the statin one.

    The doctor gives you the opportunity to take an anti-depressant, if you wish.

    If, statins, are giving us a 1 in 10,000 “risk of diabetes, liver problems and bleeding into the brain and other acknowledged side effects of statins but, again, the risks of developing these are small and far out-weighed by statin’s benefits” he says, then a doctor giving you the opportunity to take an anti-depressant is hopeless in the way Prof Baigent presents it.

    There was talk of anti=depressants causing some, if you wish, to commit suicide.
    1 in 10,000. 1 in 100,000. 1 in 1,000,000.

    Obviously, Professor Baigent has his numbers skewed, his argument skewed and his whole philosophy of medication skewed.

    Once, again, Joe Soap is either dead or suffering from a miserable life in a vortex.

    Kevin, a wonderful account of how you, so easily, showed up the MHRA for what it is and I so hope that you regain what it is you want to get back.

  7. I remember that the SSRIs did cause sexual disinterest for me while I was taking them (mostly because they created such unpleasant side-effects, no sex was the least of it in my experiences…they caused me to harm myself!) Other drugs can certainly impact ones sex life too I’ve learned. In 2006 after a forced hospitalization and being given a combo of various psych drugs including Geodon my sex life came to a sudden permanent halt. I have too much discomfort in my hip area to assume any position for sexual intercourse. The hip pain began in the hip that received an unwarranted tetanus shot at the ER before I was hoisted away to the mental health facility. One med that had been prescribed by the psychiatrist in charge who I had been seeing was a benzodiazepine. As I had experienced previous adverse reactions to that class of drugs, they probably should never have been prescribed again. But they were and the result was this forced hospitalization. Now, the odd part is that the offending drug was never withdrawn or recognized as the culprit affecting my thinking even though I documented having adverse reactions to benzos and my time there was not utilized for in-house tapering of an addictive drug, but rather used to load me up with more meds that my system could not tolerate. At one point, I fainted and was roused enough to be walked back to my room where I slept for several hours. I remember experiencing a slight full body tremor, or convulsion during that sleep. I’ve often wondered if perhaps it was some type of stroke. All I could do was go along with treatment; otherwise, I would have been judged “non-compliant” and not released. They did release me soon after I asked my husband to bring me a cane because I was having trouble walking there. I had committed no crime that brought me to the ER or this mental health center. Yet, I was forced to stay and consume drugs that I know were harming me. One drug that was administered was a blood pressure medicine that had already been discontinued because it was discovered earlier that summer that I was suffering from “white coat syndrome.” I have never encountered such disrespectful buffoonery masquerading as “health care” within written books of science. They inflicted harm, billed my insurance, I still suffer from their treatment to this day, and they continue to solicit funding for their “services.” Sometimes I wonder about the state of American health care these days. Or is it just Ohio? Thank you for allowing me to share my story.

    • Yeah what’s funny about psychiatry, if you wanna commit suicide well give you a med to stop you, if you depressed will give you a med that will make you commit suicide, if your psychotic well give you a med to make you less psychotic, if you can’t concentrate will give you a med that can make you psychotic!

      Ironic that many meds to treat sexual dysfunction are psychotropic drugs themselves and that many drugs cause it as well as psychosis are also psychotropic drugs aka halluceniations on ritalin.

  8. This story of sexual dysfunction on SSRI’s may be an anecdote – but it’s pretty compelling: In Israel, leaders of a small ultra-Orthodox sect have apparently worked with psychiatrists to get members of their flock on SSRI’s, strictly to suppress their sex drive. Teenage boys in religious schools were their first targets, but married men and women have also been steered to the “right” doctors and pressured to take these drugs.

    I ran across a mention of this in a Valentine’s Day-themed article in New Scientist, on the ethics of treating the “lovesick” with drugs, but thought it could be just a rumor. This article in the Israeli daily Ha’aretz confirms it:

    Some of the doctors actually justify their actions by pointing out how tough it is for people to experience urges that are at odds with their community’s official values and lifestyle. This in itself could lead to serious depression, they argue, if doctors don’t step in to help them manage. It’s a pretty chilling apology for social control, and one which could expand outside the religious context all too easily.

    • So they are worse then the muslims? I can’t think of any right-wing religious sect that has used drugs to surpress sex though some tribes do fgm on women, ironically places like iran,afghanistan, and saudia arabia don’t really do that.

  9. Thank you for mentioning PSSD, David.

    It’s been 2 years since I stopped venlafaxine and mirtazapine and I have ED, genital anesthesia and less pleasurable orgasms.

    Do you have any theory regarding PSSD’s etiology and how could it be reversed?

    I invite you to visit , maybe it could help you with your research.

  10. I took 3 pills of Paxil 10 Mg. I now have no emotions, blunt affect. I never get excited. I have lost interest in everything. It’s not depression… its a blankness that invades everything. I wish i was depressed… then at least I would feel something. Obviously the paxil has atrophied my brains need to produce serotonin. And yes I don’t feel love or arousal. I met my ex-girlfriend a week ago for coffee. I hadn’t seen her in 4 months. This was the girl I hoped to spend the rest of my life with. And I felt nothing. If being in a situation like that can’t jupstart my serotonin, nothing can. I only took 3 pills. I am facing a permanent change in who I am now. This drug is criminal… CRIMINAL. Paxil took my life away. Now I am a shell

  11. To the author of this post, can you list the cases where different meds were tried with no or little success in reversing the post ssri dysfunction so that our readers know what to try next. For instance ssri dysfunction persists or does only a partial reversal of symptoms even after trying say ritalin,viagara,dopamine agonists,etc.

    The problem with using SSRIs for pre-mature ejaculation is that it will take away the desire and pleasure of trying to reach the very ejaculation, if there is less desire and pleasure then you will feel worse off when its harder to reach climas, not only that you feel less satisfied, and what’s wrong with pre-mature ejaculation anyways.

  12. Those adverse reaction reports are time confusing and involve lots of paperwork and time to complete so most doctors don’t bother.

  13. Guys I don’t know why everyone is taking about sexual dysfunction. It’s not only’s the dysfunction of almost every emotions. There is nothing which can give u as much pain as this condition will.guys I don’t know what’s the need of this kind of treatment if this is the treatment.then it’s better to be untreated….its my appeal to all medical professionals please don’t put ur patients on this medicine (at any cost)……

  14. McLean JD, Forsythe RG, Kapkin IA: Unusual side effects of clomipramine associated with yawning. Can J Psychiatry. 1983 Nov;28(7):569-70. Independent psychiatrists discovered by accident that each had at least one patient who experienced orgasm when yawning while taking clomipramine. I have wondered why there has not been research conducted on this side effect in an attempt to reverse loss of libido/orgasm in many patients taking SSRIs..

  15. Hi,

    25 year old male suffering impotence for the last 3 years due to two weeks on an SSRI (Citalopram for one week and Sertraline for another)
    This is basically murder, seeing as they kill who you were beforehand and leave you with the shell of the person you now are!
    I am completely impotent thanks to this and it makes having a relationship impossible!

  16. Hi, all! I have severe PSSD for 4 years now. No libido, arousal, problems with keeping erection, etc.
    But this year I found out I can still get extremely horny, even hornier than pre-pssd. On demand. That it’s not impossible. Have extremely enjoyable sex for hours and hours. How? Methamphetamine.

  17. That just proves Wikipedia is utterly, utterly evil. This is an utterly gratuitous, malignant, egocentric action. I haven’t even read the comments, because there will be at least two or three of those as well.. The internet is pure pestilence, and not least of all its supposed “guardians” (self-appointed kings)

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