Study 329

If someone were to ask the surviving authors of Study 329 the question: "Knowing what you know now, if you had to do it over, would you agree to participate in that study again?", many would probably say no. The real title of Study 329 was “Efficacy of Paroxetine in the Treatment of Adolescent Major Depression, A Randomized Controlled Trial”. It was published in the Journal of … [Read more...] about The Troubled Life of Study 329: Consequences of Failure to Retract

    MARTIN B. KELLER, M.D.   Brown University Martin B. Keller Professor Emeritus of Psychiatry and Human Behavior Martin_Keller@brown.edu Martin Keller has made major research contributions to the understanding and treatment of mood disorders. He has performed research on the longitudinal course and neuropsychopharmacology of affective disorders … [Read more...] about Original Study 329 Team

Faced in 2012 with questions about the $3 Billion fine imposed on GSK - triggered by a sequence of events starting with Study 329, – is it just the cost of doing business? Andrew Witty snapped back: “Although corporate malfeasance cases end up looking very big, they often have their origin in just… one or two people who didn’t quite do the right thing. It’s not about the big … [Read more...] about Study329.org: Science with a Conscience

In addition to hosting the Panorama programs and The Famous Grouse history of Study 329, Study329.org has a comprehensive timeline on the origins of concerns about the SSRIs and the risk of suicide - initially with Prozac and subsequently with Paxil - Seroxat. The chronology is laid out year on year with key documents linked to many of these years. Click on the year, then … [Read more...] about Study 329: The Timelines

Study 329 is probably the most famous clinical trial ever. It is one of the few to attract a Fraud action and is certainly the only one with a $3 Billion fine linked to it. See A Milestone in Drug Safety. The study began recruiting adolescents to Paxil, imipramine or placebo in 1994 and finished up in 1998. Later in 1998, SmithKline Beecham, the marketers of Paxil (they … [Read more...] about Study329.org: The Panorama Files

Study 329: The final chapter coming soon Arguably the most controversial drug study ever, Study 329, published in July 2001: Concluded that paroxetine was a safe and effective medication for treating major depression in adolescents; Is still widely cited in the medical literature, providing physicians with assurance about the usefulness of paroxetine; Was criticized … [Read more...] about A Milestone in the Battle for Truth in Drug Safety