This post by Peter Selley centres on a Moderna RSV vaccine trial, the Rhyme trial, in young babies that was stopped last year when 7 out of 40 babies between 5 and 8 months of age developed severe lung disease, compared to 1 in 20 controls. Moderna had good reason to think its vaccine could cause this, as you will see, but the company appears to have opted to overlook the … [Read more...] about The Respiratory Syncytial Virus Challenge
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Antidepressants Alcohol and Anne-Marie
Among the greatest triumphs linked to RxISK was Anne-Marie Kelly's discovery that SSRI antidepressants can cause alcohol misuse. A Hero Anne-Marie's story was first told in Out of My Mind Driven to Drink, which featured here in March 2012. This led to a post on RxISK Driven to Drink. Between them the posts have over 450 comments, a huge proportion of which say this describes … [Read more...] about Antidepressants Alcohol and Anne-Marie
Kingston’s Rule
This post is written by Dr Pedro who is watching events unfold from 10,000 miles away - with some extras added at the end. The UK Royal College of General Practitioners (RCGP) has been asked by Katy Skerrett, Senior Coroner for Gloucestershire, to respond to her Regulation 28 report to Prevent Future Deaths, after the inquest of Thomas Kingston (above). His death seemed to … [Read more...] about Kingston’s Rule
A Turning Point in History
That time of year thou mayst in me behold When yellow leaves, or none, or few do hang Upon those boughs which shake against the cold Bare ruined choirs where late the sweet birds sang. Shakespeare Sonnet 73 These lines came to mind recently when walking by a school playground crowded with young children on lunch-break. Like birds chirping in a tree or bush, they were … [Read more...] about A Turning Point in History
The Darkness and the Light
A Darkness the Light cannot Master A priming note for Secular and all non-Xtian readers - what Xtians call the New Testament has 4 Gospels. Three open with variations on what most folk from Hollywood to the Vatican would view as the conventional Xmas Nativity story – cold time of year, manger, donkeys, star. The fourth, the Gospel according to John, is radically different. … [Read more...] about The Darkness and the Light
Probity Blockers and Trans Medicine
Never before in human history have so many had to entrust their lives and wellbeing to so few and been so betrayed. Inspired by Winston Churchill The further a society drifts from the truth the more it will hate those who speak it Inspired by Winston Smith Probity Blockers, a term originally coined by Dee Mangin, were a big talking point on RxISK in 2024 and … [Read more...] about Probity Blockers and Trans Medicine
Aunts, Ants and Regulators
Thanks for this post goes to Annie Bevan who for over a decade has made some amazing contributions to DH and RxISK. None more so than finding a document sitting in front of all of us for two decades that should make regulators blush, squirm and wish the ground would open and swallow them. Thomas Kingston Tom Kingston's unfortunate death earlier this year led to an inquest a … [Read more...] about Aunts, Ants and Regulators
Medical Assistance in Dying
After 6 deaths, 6 years ago, on November 17, two days ago, the New Zealand Herald featured an article reporting on an inquest into these deaths. The original with photos of the 6 children is linked. The text is below the link. The action in this post happens right at the bottom of the NZH article and beyond. Fluoxetine use in teenager scrutinised in youth suicide inquest A … [Read more...] about Medical Assistance in Dying
Clearing the Deck Post-Prozac
Prozac (fluoxetine) went off patent in August 2021. In July 2000, FDA approved Sarafem (fluoxetine) for use in Pre-Menstrual Dysphoric Disorder (PMDD). In June 2010, Lilly stopped marketing Sarafem. In August 2023, Lilly informed FDA they wished to Withdraw Sarafem and its PMDD indication. It is not exactly clear what withdrawing its PMDD indication means. Presumably all … [Read more...] about Clearing the Deck Post-Prozac
The Prozac Era. What Next?
In 1963, Hoffman la Roche launched Valium, the brand name for diazepam, a benzodiazepine. It followed hot on the heels of Librium - chlordiazepoxide - another benzodiazepine. This was like one company producing 2 SSRIs and able to get them to numbers 1 and 2 in the charts. Arthur Sackler of Purdue and Oxycontin fame devised the marketing. This is where the money came from … [Read more...] about The Prozac Era. What Next?