RxISK Stories – Withdrawal from Clopidogrel

August, 23, 2012 | 6 Comments


  1. There was a study published in the US a few years ago apparently, confirming a “Plavix rebound” effect. The first 90 days after stopping clopidogrel turned out to be a very risky period for heart attacks and strokes. It was written up in the business press … where else, right? This is from the pharma-biz blog Fierce Pharma:


    They helpfully suggest that folks could avoid the danger by just taking Plavix forever. They have no idea if that’ll be good for you, but it’ll be wonderful for Bristol-Myers Squibb’s bottom line! (I bet that of those doctors who have seen this happen, most of them just regard it as evidence that the patient was sicker than she looked, and Plavix is even more wonderful than we thought.)

    The full article from Journal of the American Medical Assn (JAMA) is here … may be a useful thing for people in Fiona’s position to show their doctors:


  2. i had a similar experience with prozac.i stopped taking it and suffered terrible withdrawal.headaches,vomiting ,numbness,chronic stomach and back pain,swollen face,burning skin,visual problems,severe detatchment from reality,chronic muscle cramps,thoughts of suicide and violence.thoughts of homicide,unable to conrol myself,vivid nightmares,severe dizzieness.the list of side effects or effects they dont want you to know about when they prescribe them.as thats what they are really.gos on and on.every doctor told me it couldnt be the prozac.they were very negative and accused me of being mentally unstable.with one psychiatrist even writing a very bad report on me.i still suffer to this day because of the crap information i was given.i have never been ill in my life.i went to the doctor with anxiety after getting attacked and ended with my life ruined .because i trusted my doctor not to lie.they know nothing about what these drugs do to people.nor do they want to know.they are ignorant fools who dont care about people.they only care about money.i will never trust another doctor or take another drug.SSRIs are poison.they should be banned.

  3. I found this iste after quitting Clopidegrel as I found I felt sick and had tingling in my hand and weakness in my arm.

  4. I am trying to stop Clopidogrel a year after a slight heart attack when tests didnt reveal any heart problem, they think maybe a blood clot. The first time I got bad anxiety, pains, just feeling bad. I ended up in a&e with bad anxiety. Have belching, a sore digestion system, just feel bloated and having a need to move around. Difficult to explain. Trying again and symptoms have returned. Cardiologist said should just stop taking it but I read that should do it slowly. Down to half a tablet in a week. Also taking 75mg aspirin. I am concerned about coming off this drug and will continue but even slower now. People should be warned and be under close observation whilst coming off clopidogrel.

  5. I am on Clopidogrel, Lipitor, Atenolol and low does aspirin since 3/2015 from slight heart attack. The bruising is concerning, but after this amount of time I started to get a very oily scalp and losing hair. Very itchy scalp and constipation. I remembered that yeast overgrowth in the entire body (starts in the gut) is a very real result of taking prescription drugs. I am using way more than the recommended dose of probiotics (friendly bacteria already present in the body that drugs kill). I take several throughout the day. My digestion (no bloating, less gas, less acid reflux) is better as is my elimination. My urine doesn’t smell anymore and my hair and scalp are beginning to be normal again.

    I plan to start coming off the Clopidogrel and Lipitor on my own. I have already made very significant improvements in my diet. I don’t trust doctors much either. They treat me like a child at the appointments and don’t want to answer my questions in detail.

    • Hi CKE
      I had a mild heart attack in Jan 2014 and was put on Clopidogrel, Atorvastatin and low dose aspirin. I was covered in large bruises, I had lots of anxiety, chest pains, leg pains, stomach problems, basically I felt bad. After lots of tests didn’t show anything up apart from a normal mild regurgitating tricuspid valve it was decided I had a small blood clot probably from being hypothyroid and under immense stress on that particular day. I was worried about everything, the pains, kept thinking I was going to have another heart attack. Was sent to a psychologist and had good and bad days. They I decided that enough was enough and that I was going to come off the drugs. I emailed Dr Sinatra what I could take that would do the same thing as the drugs, I bought the latest ebooks from the integrative cardiologists all about the essential nutrients etc. But I have made a massive recovery, my regimen has been to take Nattokinase and Serrapeptase. I sleep on a grounding mat to get rid of clots. I take a glandular thyroid for the T3. I take D-Ribose powder three times a day for the ATP energy. CoQ10 Ubiquinole, Krill Oil, DHA oil, selenium, magnesium citrate as I was low, zinc as I was below low, a good multi vit, D3 3000iu, Himalayan Salt, kelp, garlic, ashwagandha and rhodiola for stress, B6 and high B vits, resveratrol. I downloaded some hypnosis tapes for relaxation, after heart attack, I walk fast twice a day in the countryside, 1500mg methylcobalamin B12. I got rid of the statins with plant sterols, the aspirin and Clopidogrel has been banished. I make sure I drink water throughout the day and eat a couple of bananas a day with fruit and vegetables. I have gone gluten, grain and dairy free with no sugar just stevia and green tea with a little red wine and water for a treat and dark chocolate. I sometimes get a chest pain but its always if I have lifted some shopping etc, I think its a bit of costo chondritis but that has got a lot better. I sometimes have bouts of palpitations but that can be from my thyroid or something I have eaten. I was getting anxiety attacks but now I realise it was from sugar spikes from potatoes, I now eat sweet potatoes. But the drugs did give me a lot of side effects like pains in my skull, bruising, breathlessness. I don’t go mad and push myself but I can walk fast up an incline but I would pace myself going up a steep hill, or even take the bus! I found I had to be brave and take the leap, it was scary and I went back on the drugs because I was too scared but I fought through it and now I have forgotten about it. I watch what I eat, eggs for breakfast with fruit, vine fruit gluten and grain free cereal with coconut yoghurt and almond milk with fish and vegetables and banana with yoghurt. I continue to take my supplements as I had mild adrenal fatigue. Since the heart attack I have lost over 3.5 stone, gone from a size 20 to a `14 all because of my hypothyroid. I have since been diagnosed with Hashimotos so I am aware when I am low on thyroid and take a glandular. I have learnt to listen to my body and do the latest research on nutrients etc. My doctor didn’t listen to me so I just did it on my own, stopped the prescriptions and forgotten about it. They wanted to put me back on clopidogrel without even seeing me or telling me why. My Mum took Clopidogrel and I noticed a few days after that she started having memory problems and its just got worse. The doctor told me that statins cause memory problems and on the next prescription statins had been prescribed, they don’t listen to themselves. I would rather go to a witch doctor and be given herbs than take drugs. Good luck, Dr Sinatra has lots of information on the website and I would rather trust him than my cardiologist who didn’t know that if you take statins you should take CoQ10! It killed my Dad who died of heart failure on lots of drugs, he was a fit cyclist in his 80’s before they got him with drugs. Good luck, go for it, not sure about the other drug. Just noticed I had posted here as I was coming off the drug. Well, here I am, I made it and feel 100% better. My Mum has also come off Clopidogrel and is taking Serrapeptase and Nattokinase and her nasty bruises have gone. She is 91 and walking fast and still living in her home alone, she only takes Levothyroxine now plus supplements.

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