RxISK Stories – Withdrawal from Clopidogrel

August, 23, 2012 | 10 Comments


  1. There was a study published in the US a few years ago apparently, confirming a “Plavix rebound” effect. The first 90 days after stopping clopidogrel turned out to be a very risky period for heart attacks and strokes. It was written up in the business press … where else, right? This is from the pharma-biz blog Fierce Pharma:


    They helpfully suggest that folks could avoid the danger by just taking Plavix forever. They have no idea if that’ll be good for you, but it’ll be wonderful for Bristol-Myers Squibb’s bottom line! (I bet that of those doctors who have seen this happen, most of them just regard it as evidence that the patient was sicker than she looked, and Plavix is even more wonderful than we thought.)

    The full article from Journal of the American Medical Assn (JAMA) is here … may be a useful thing for people in Fiona’s position to show their doctors:


  2. i had a similar experience with prozac.i stopped taking it and suffered terrible withdrawal.headaches,vomiting ,numbness,chronic stomach and back pain,swollen face,burning skin,visual problems,severe detatchment from reality,chronic muscle cramps,thoughts of suicide and violence.thoughts of homicide,unable to conrol myself,vivid nightmares,severe dizzieness.the list of side effects or effects they dont want you to know about when they prescribe them.as thats what they are really.gos on and on.every doctor told me it couldnt be the prozac.they were very negative and accused me of being mentally unstable.with one psychiatrist even writing a very bad report on me.i still suffer to this day because of the crap information i was given.i have never been ill in my life.i went to the doctor with anxiety after getting attacked and ended with my life ruined .because i trusted my doctor not to lie.they know nothing about what these drugs do to people.nor do they want to know.they are ignorant fools who dont care about people.they only care about money.i will never trust another doctor or take another drug.SSRIs are poison.they should be banned.

  3. I found this iste after quitting Clopidegrel as I found I felt sick and had tingling in my hand and weakness in my arm.

  4. I am trying to stop Clopidogrel a year after a slight heart attack when tests didnt reveal any heart problem, they think maybe a blood clot. The first time I got bad anxiety, pains, just feeling bad. I ended up in a&e with bad anxiety. Have belching, a sore digestion system, just feel bloated and having a need to move around. Difficult to explain. Trying again and symptoms have returned. Cardiologist said should just stop taking it but I read that should do it slowly. Down to half a tablet in a week. Also taking 75mg aspirin. I am concerned about coming off this drug and will continue but even slower now. People should be warned and be under close observation whilst coming off clopidogrel.

    • I just wanted to update on my health now. I take a Nattokinase in the morning along with Serrapeptase and also a Serrapeptase in the evening. I also make sure I drink enough and keep up with magnesium citrate, zinc picolinate in the evening. I walk once or twice a day, take vitamin E with krill oil and try and avoid sugar using stevia instead. I have now come off levothyroxine and gone onto natural dessicated thyroid and feel so much better. I also take Taurine for a strong heart, D-Ribose for ATP energy, coconut water for electrolyte balance, potassium and magnesium. I used to have days of palpitations but just increasing my magnesium has stopped them along with Taurine and increasing my thyroid slightly. I don’t take aspirin as I think it was giving me leaky gut and I take gellatine which has greatly helped my absorption of nutrients. I was scared at first and gently increased my confidence. I don’t belch anymore or have sore digestion system. I have also found my gluten intolerance and sugar tolerance have improved. I did my research and now a year later I am feeling GREAT! I also take ashwagandha and rhodiola for stress so I stay calm no matter what now. My anxiety has disappeared I think mostly to ashwagandha and rhodiola and sorting out my hypothyroid.

  5. I am on Clopidogrel, Lipitor, Atenolol and low does aspirin since 3/2015 from slight heart attack. The bruising is concerning, but after this amount of time I started to get a very oily scalp and losing hair. Very itchy scalp and constipation. I remembered that yeast overgrowth in the entire body (starts in the gut) is a very real result of taking prescription drugs. I am using way more than the recommended dose of probiotics (friendly bacteria already present in the body that drugs kill). I take several throughout the day. My digestion (no bloating, less gas, less acid reflux) is better as is my elimination. My urine doesn’t smell anymore and my hair and scalp are beginning to be normal again.

    I plan to start coming off the Clopidogrel and Lipitor on my own. I have already made very significant improvements in my diet. I don’t trust doctors much either. They treat me like a child at the appointments and don’t want to answer my questions in detail.

    • Hi CKE
      I had a mild heart attack in Jan 2014 and was put on Clopidogrel, Atorvastatin and low dose aspirin. I was covered in large bruises, I had lots of anxiety, chest pains, leg pains, stomach problems, basically I felt bad. After lots of tests didn’t show anything up apart from a normal mild regurgitating tricuspid valve it was decided I had a small blood clot probably from being hypothyroid and under immense stress on that particular day. I was worried about everything, the pains, kept thinking I was going to have another heart attack. Was sent to a psychologist and had good and bad days. They I decided that enough was enough and that I was going to come off the drugs. I emailed Dr Sinatra what I could take that would do the same thing as the drugs, I bought the latest ebooks from the integrative cardiologists all about the essential nutrients etc. But I have made a massive recovery, my regimen has been to take Nattokinase and Serrapeptase. I sleep on a grounding mat to get rid of clots. I take a glandular thyroid for the T3. I take D-Ribose powder three times a day for the ATP energy. CoQ10 Ubiquinole, Krill Oil, DHA oil, selenium, magnesium citrate as I was low, zinc as I was below low, a good multi vit, D3 3000iu, Himalayan Salt, kelp, garlic, ashwagandha and rhodiola for stress, B6 and high B vits, resveratrol. I downloaded some hypnosis tapes for relaxation, after heart attack, I walk fast twice a day in the countryside, 1500mg methylcobalamin B12. I got rid of the statins with plant sterols, the aspirin and Clopidogrel has been banished. I make sure I drink water throughout the day and eat a couple of bananas a day with fruit and vegetables. I have gone gluten, grain and dairy free with no sugar just stevia and green tea with a little red wine and water for a treat and dark chocolate. I sometimes get a chest pain but its always if I have lifted some shopping etc, I think its a bit of costo chondritis but that has got a lot better. I sometimes have bouts of palpitations but that can be from my thyroid or something I have eaten. I was getting anxiety attacks but now I realise it was from sugar spikes from potatoes, I now eat sweet potatoes. But the drugs did give me a lot of side effects like pains in my skull, bruising, breathlessness. I don’t go mad and push myself but I can walk fast up an incline but I would pace myself going up a steep hill, or even take the bus! I found I had to be brave and take the leap, it was scary and I went back on the drugs because I was too scared but I fought through it and now I have forgotten about it. I watch what I eat, eggs for breakfast with fruit, vine fruit gluten and grain free cereal with coconut yoghurt and almond milk with fish and vegetables and banana with yoghurt. I continue to take my supplements as I had mild adrenal fatigue. Since the heart attack I have lost over 3.5 stone, gone from a size 20 to a `14 all because of my hypothyroid. I have since been diagnosed with Hashimotos so I am aware when I am low on thyroid and take a glandular. I have learnt to listen to my body and do the latest research on nutrients etc. My doctor didn’t listen to me so I just did it on my own, stopped the prescriptions and forgotten about it. They wanted to put me back on clopidogrel without even seeing me or telling me why. My Mum took Clopidogrel and I noticed a few days after that she started having memory problems and its just got worse. The doctor told me that statins cause memory problems and on the next prescription statins had been prescribed, they don’t listen to themselves. I would rather go to a witch doctor and be given herbs than take drugs. Good luck, Dr Sinatra has lots of information on the website and I would rather trust him than my cardiologist who didn’t know that if you take statins you should take CoQ10! It killed my Dad who died of heart failure on lots of drugs, he was a fit cyclist in his 80’s before they got him with drugs. Good luck, go for it, not sure about the other drug. Just noticed I had posted here as I was coming off the drug. Well, here I am, I made it and feel 100% better. My Mum has also come off Clopidogrel and is taking Serrapeptase and Nattokinase and her nasty bruises have gone. She is 91 and walking fast and still living in her home alone, she only takes Levothyroxine now plus supplements.

      • Hi Lou,
        It is very heartening to read that you have successfully come off Clopidogrel. I have been taking it for 3 years following severe dizzy spells and being diagnosed as having had small strokes due to small vessel disease.
        I have improved my diet and have been really healthy until recently when I have had to admit to have all the symptoms of IBS( irritable bowel syndrome) which is ruining my life. I am also getting headaches.
        I have been continuing using the drug through fear but have had doubts that it is ruining my stomach lining and digestion. I have been scared to come off it but having read your story, am going to try your supplement regime.
        I have a few questions:
        Did you start the supplements before coming off Clopidogrel?
        Did you come off slowly and how slow?
        How did you know which supplements to try?
        I am grateful for any qui dance.
        Thank you

        • Hi Christine
          That is very interesting that you now have IBS, I feel as though my nutrient absorption is low, I am eating very healthily but feel as though I have aged faster since taking Clopidgrel, aspirin and statins.
          I started for 5 days on .75 the dose and took one Nattokinase, then another 5 days for .5 a dose, then 5 days on .25 and I took Serrapeptase as well and then after 5 days withdrew completely. But I then reduced the aspirin. Just watch out for any more bleeding and make adjustments. My doctor just said to stop Clopidogrel but I just felt I couldn’t, maybe anxiety or just a ‘feeling’ but there is no harm in taking it slow.
          I did email Dr Sinatra who sent me a personal reply, if I was you I would contact him, he has lots of information on his website.
          I also have hypothyroid so take supplements for this.
          I take high DHA omega 3, sea buckthorn, resveratrol, Ubiquinol CoQ10, d-ribose powder, MSM for inflammation, high dose b vitamins, B12 methylcobalamin, high vit D sublingual spray, vitamin c 2000 slow release, magnesium citrate, zinc, glucosamine, ashwagandha and rhodiola for stress, iron and I sleep on a grounding mat. I now only take levothyroxine and no blood thinners, I don’t bruise easily anymore. I go for two 30 min walks a day which I actually enjoy now. I have got rid of my anxiety and I relax more. I also drink green tea with stevia and I have no sugar whatsoever and I stay off cakes except the odd ocassions. I also eat at least a couple of bananas a day for the potassium, taurine before bed, vitamin K2 to keep calcium in the bones and out of the system and B6 before bed. I have two eggs for breakfast with himalayan salt, I enjoy cream with blueberries, dark chocolate and don’t have gluten, grains, dairy. I also have organic bio coconut yogurt on vine fruit cereal with almond milk. Lots of salads and vegetables with salmon, mackeral and sometimes lean steak. I also keep up the research. I did have a heart attack and they didn’t find anything wrong with my vessels and I don’t get dizzy so I would contact Dr Sinatra for the way forward. My Mum had a TIA and serrapeptase can dissolve clots. The grounding mat helps the blood. Perhaps you have a thyroid issue with dizzy spells! Good luck Lou x

  6. I had a heart stendt 7.5 years ago,at which time I was placed on Plavix. On a recent visit to my cardiologist I complained of prolonged acid relfux where I would wake up at night spitting up bloody acid and could not catch air to my lungs because my throat was burned close. He told me to stop the Plavix after 7.5 years and just take a baby aspirin once a day and not worry about it. Prior to this he was telling me I probably would need to take Plavix the rest of my life because of my high cholesterol. I stopped Plavix one month ago and I have had several days when I really feal bad and I am scared to death.I also have bad dreams,insomnia,bloating and a 20 pound weight gain.. Now they want to inject me with Repatha for cholesterol. I took it upon myself to take a Plavix every third day,and aspirin on the other days. Cant say yet if this is helping, but I am at a total loss not knowing what to do.

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